<<返回上一页

A tale of destiny and dentistry

发布时间:2019-03-08 01:13:16来源:未知点击:

WHAT makes some teeth become chomping molars while others become piercing incisors? The answer is a single protein, say researchers who have studied tooth development in mice. In experiments with mouse embryos, Paul Sharpe and his colleagues at Guy’s Hospital in London showed that a protein called BMP-4 inhibits a gene that makes teeth develop as molars. BMP-4 is usually only found in the region where incisors are supposed to appear. In mouse embryos that lacked BMP-4, all the would-be incisors grew into molars (Science, vol 282, p 1136). Sharpe speculates that one day, gene therapy and a better understanding of the genetics of tooth development could allow dental patients to grow new teeth. “It’s a long way off, but we’re moving in the right direction,